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Test Code AMINQN Amino Acids, Quantitative, Plasma

Additional Codes

 

MAYO Test ID

AAQP

EPIC Test ID

LAB811

 

Reporting Name

Amino Acids, QN, P

Useful For

Evaluating patients with possible inborn errors of metabolism

 

May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns

Testing Algorithm

Includes quantitation of the following amino acids: taurine, threonine, serine, asparagine, glutamic acid, glutamine, proline, alanine, citrulline, alpha-amino-n-butyric acid, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, beta-alanine, ornithine, lysine, histidine, argininosuccinic acid, allo-isoleucine, arginine, phosphoserine, phosphoethanolamine, hydroxyproline, glycine, aspartic acid, ethanolamine, sarcosine, 1-methylhistidine, 3-methylhistidine, carnosine, anserine, homocitruline, alpha-aminoadipic acid, gamma-amino-n-butyric acid, beta-aminoisobutyric acid, hydroxylysine, cystathionine, and tryptophan.

Method Name

Quantitative Analysis by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma


Additional Testing Requirements


Not all patients with homocystinuria will be detected by this assay. If there is a concern for homocystinuria, please order HCYSU / Homocysteine, Total, Urine in tandem with amino acids.

Necessary Information


1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.



Specimen Required


Patient Preparation

Fasting (overnight preferred, 4 hours minimum). Infants should be drawn just before next feeding (2-3 hours without TPN if possible).

 

Collection Container/Tube:

Preferred: Green top (sodium heparin)

Acceptable: EDTA, PST, lithium heparin

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge within 4 hours if specimen is stored at refrigerated temperature and aliquot plasma. Send plasma frozen.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Frozen 14 days

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

Thrombin-activated tube

Reference Values

Plasma Amino Acid Reference Values (nmol/mL)

Age Groups

<24 Months (n=191)

2-17 Years (n=441)

≥18 Years (n=148)

Phosphoserine (PSer)

<109

<95

<18

Phosphoethanolamine (PEtN)

<6

<5

<12

Taurine (Tau)

37-177

38-153

42-156

Asparagine (Asn)

25-91

29-87

37-92

Serine (Ser)

69-271

71-208

63-187

Hydroxyproline (Hyp)

8-61

7-35

4-29

Glycine (Gly)

111-426

149-417

126-490

Glutamine (Gln)

316-1020

329-976

371-957

Aspartic Acid (Asp)

2-20

<11

<7

Ethanolamine (EtN)

<70

<64

<67

Histidine (His)

10-116

12-132

39-123

Threonine (Thr)

47-237

58-195

85-231

Citrulline (Cit)

9-38

11-45

17-46

Sarcosine (Sar)

<5

<5

<5

b-Alanine (bAla)

<28

<27

<29

Alanine (Ala)

139-474

144-557

200-579

Glutamic Acid (Glu)

31-202

22-131

13-113

1-Methylhistidine (1MHis)

<11

<20

<28

3-Methylhistidine (3MHis)

<1

<1

2-9

Argininosuccinic Acid (Asa)

<2

<2

<2

Carnosine (Car)

<13

<1

<1

Anserine (Ans)

<1

<1

<1

Homocitruline (Hcit)

<5

<2

<2

Arginine (Arg)

29-134

31-132

32-120

a-Aminoadipic Acid (Aad)

<4

<3

<3

g-Amino-n-butyric Acid (GABA)

<4

<3

<2

b-Aminoisobutyric Acid (bAib)

<9

<5

<5

a-Amino-n-butyric Acid (Abu)

7-28

7-31

9-37

Hydroxylysine (Hyl)

<4

<3

<2

Proline (Pro)

85-303

80-357

97-368

Ornithine (Orn)

20-130

22-97

38-130

Cystathionine (Cth)

<2

<2

<5

Cystine (Cys)

2-32

2-36

3-95

Lysine (Lys)

49-204

59-240

103-255

Methionine (Met)

11-35

11-37

4-44

Valine (Val)

83-300

106-320

136-309

Tyrosine (Tyr)

26-115

31-106

31-90

Isoleucine (IIe)

31-105

30-111

36-107

Leucine (Leu)

48-175

51-196

68-183

Phenylalanine (Phe)

28-80

30-95

35-80

Tryptophan (Trp)

17-75

23-80

29-77

Alloisoleucine (Allolle)

<2

<3

<5

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.

CPT Code Information

82139

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AAQP Amino Acids, QN, P In Process

 

Result ID Test Result Name Result LOINC Value
34449 Phosphoserine 20654-0
34457 Phosphoethanolamine 26612-2
3512 Taurine 20657-3
3517 Asparagine 20638-3
3516 Serine 20656-5
34458 Hydroxyproline 20647-4
3522 Glycine 20644-1
3518 Glutamine 20643-3
34459 Aspartic Acid 20639-1
34460 Ethanolamine 26608-0
3535 Histidine 20645-8
3515 Threonine 20658-1
3521 Citrulline 20640-9
34461 Sarcosine 26613-0
3532 Beta-Alanine 26604-9
3523 Alanine 20636-7
3520 Glutamic Acid 20642-5
34453 1-Methylhistidine 20633-4
34454 3-Methylhistidine 20635-9
32341 Argininosuccinic Acid 32227-1
34455 Carnosine 26606-4
34462 Anserine 26599-1
34456 Homocitrulline 55876-7
3536 Arginine 20637-5
34450 Alpha-aminoadipic Acid 26600-7
34463 Gamma-amino-n-butyric Acid 26609-8
34452 Beta-aminoisobutyric Acid 26605-6
3524 Alpha-amino-n-butyric Acid 20634-2
34464 Hydroxylysine 26610-6
3519 Proline 20655-7
3533 Ornithine 20652-4
34451 Cystathionine 26607-2
3526 Cystine 22672-0
3534 Lysine 20650-8
3527 Methionine 20651-6
3525 Valine 20661-5
3530 Tyrosine 20660-7
3528 Isoleucine 20648-2
3529 Leucine 20649-0
3531 Phenylalanine 14875-9
34465 Tryptophan 20659-9
32347 Allo-isoleucine 22670-4
3570 Interpretation (AAQP) 49247-0

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Analytic Time

3 days (not reported on Saturday or Sunday)