Sign in →

Test Code AMPIP Amyloid Protein Identification, Paraffin, LC-MS/MS

Shipping Instructions

Attach the green pathology address label included in the kit to the outside of the transport container.

Necessary Information

1. Preliminary pathology report and history are required.

2. A brief explanatory note or consultative letter is also recommended.

Specimen Required

Supplies: Pathology Packaging Kit (T554)

Specimen Type: Formalin-fixed or B5-fixed, paraffin-embedded tissue block

Container/Tube: Pathology Packaging Kit (T554)

Collection Instructions: Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.

Useful For

Definitive identification of amyloid proteins

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
MLCPC Microdissection, Laser Capture No No
MSPTC Mass Spectrometry No No

Testing Algorithm

In all cases with adequate tissue, an initial Congo red stain is performed before mass spectrometry testing to confirm positivity and pattern of amyloid deposition can be considered when interpreting mass spectrometry results. A pathology consultation is typically not required. If the amyloid subtyping results do not fit the clinical findings, a PATHC / Pathology Consultation may be added if appropriate, upon client approval.


See Laboratory Approach to the Diagnosis of Amyloidosis in Special Instructions.

Method Name

Histological Stain

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Amyloid Protein ID, Par, LC MS/MS

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time
AMYLOID Ambient (preferred)

Reject Due To








Fixed tissue slides

Wet/Frozen Tissue

Cytological Smears

Nonformalin fixed tissue

Nonparaffin embedded tissue

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

7-15 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


82542 (if appropriate)

88380 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AMPIP Amyloid Protein ID, Par, LC MS/MS In Process


Result ID Test Result Name Result LOINC Value
71185 Interpretation 50595-8
71186 Participated in the Interpretation No LOINC Needed
71187 Report electronically signed by 19139-5
71189 Material Received 81178-6
71592 Disclaimer 62364-5
72109 Case Number In Process