Sign in →

Test Code CRYOGM Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma

Additional Codes

MAYO Test ID

CRGSP

EPIC Test ID

LAB713

 

 

Reporting Name

Cryo Panel, S and P

Useful For

Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRY_S Cryoglobulin, S Yes Yes
CRY_P Cryofibrinogen, P No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a result other than negative, then immunofixation will be performed at an additional charge. Positive cryoglobulins of ≥0.1 mL of precipitate will be typed once.

Method Name

CRY_S, CRY_P: Quantitation and Qualitative Typing Precipitation at 1 Degree C

Includes cryofibrinogen.

IMFXC: Immunofixation

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma EDTA
Serum
St. Lukes Hospital Cedar Rapids Note:

Note: BOTH serum and plasma is required. Special processing of sample needed, see specimen requirements.


Specimen Required


Plasma and serum are required.

 

Cryofibrinogen

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of plasma from red cells.

3. Place plasma into an appropriately labeled plastic vial.

 

Cryoglobulin

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of serum from red cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with <3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require draw of a new specimen.


Specimen Minimum Volume

Serum: 3 mL/Plasma: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Refrigerated (preferred)
  Frozen 
Serum Refrigerated (preferred)
  Frozen 

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

Serum gel tube or plasma gel tube

Reference Values

CRYOGLOBULIN

Negative (positives reported as percent)

If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.

 

CRYOFIBRINOGEN

Negative

Quantitation and immunotyping will not be performed on positive cryofibrinogen.

Day(s) and Time(s) Performed

Monday through Friday; 4 p.m.

CPT Code Information

82585-Cryofibrinogen

82595-Cryoglobulin

86334-Immunofixation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRGSP Cryo Panel, S and P In Process

 

Result ID Test Result Name Result LOINC Value
2685 Cryofibrinogen, P 11043-7
2684 Cryoglobulin, S 15174-6

Analytic Time

2 days

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

Hematopathology/Cytogenetics Test Request Form (T726) (http://www.mayomedicallaboratories.com/it-mmfiles/hematopathology-request-form.pdf)

Benign Hematology Test Request Form (T755) (http://www.mayomedicallaboratories.com/it-mmfiles/benign-hematology-test-request-form.pdf)