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Test Code CTDCM Connective Tissue Diseases Cascade, Serum

Additional Codes

MAYO Test ID

CTDC

EPIC Test ID

LAB2375

 

 

Reporting Name

Connective Tissue Disease Cascade,S

Useful For

Evaluation of patients with signs and symptoms compatible with connective tissue diseases

Profile Information

Test ID Reporting Name Available Separately Always Performed
ANA2 Antinuclear Ab, S Yes Yes
CCP Cyclic Citrullinated Peptide Ab, S Yes Yes
IM_01 Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
CMA Centromere Ab, IgG, S Yes No
CASMT ANA2 Cascade No No
RIB Ribosome P Ab, IgG, S Yes No
ENAE Ab to Extractable Nuclear Ag Eval,S Yes No
ADNAR dsDNA Ab with Reflex, IgG, S Yes No

Testing Algorithm

If antinuclear antibodies are ≥3.0 U, then antibodies to double-stranded DNA (dsDNA), extractable nuclear antigen evaluation, ribosome P, and centromere are performed at an additional charge.

 

If result from dsDNA test is borderline, then dsDNA antibody by Crithidia IFA will be performed at an additional charge.

 

See Connective Tissue Disease Cascade (CTDC) in Special Instructions.

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL


Specimen Minimum Volume

0.7 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

NA

Reference Values

ANTINUCLEAR ANTIBODIES (ANA)

≤1.0 U (negative)

1.1-2.9 U (weakly positive)

3.0-5.9 U (positive)

≥6.0 U (strongly positive)

Reference values apply to all ages.

 

CYCLIC CITRULLINATED PEPTIDE ANTIBODIES, IgG

<20.0 U (negative)

20.0-39.9 U (weak positive)

40.0-59.9 U (positive)

≥60.0 U (strong positive) 

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Saturday; 4 p.m.

CPT Code Information

86038-ANA

86200-Cyclic citrullinated peptide antibodies, IgG

83516-Centromere (if appropriate)

83516-Ribosome (if appropriate)

86225-ds-DNA Ab with Reflex (if appropriate)

86255-ds-DNA Ab by Crithidia IFA (if appropriate)

86235 x 6-RNP, Sm, SS-B, SS-A, Jo 1, and Scl 70 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CTDC Connective Tissue Disease Cascade,S In Process

 

Result ID Test Result Name Result LOINC Value
ANA2 Antinuclear Ab, S 5047-6
CCP Cyclic Citrullinated Peptide Ab, S 32218-0
IM_01 Interpretation In Process

Analytic Time

3 days

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Forms

If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf)