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Test Code HCSRN Hepatitis C Antibody Screen with Reflex to HCV RNA by PCR, Serum

Specimen Required

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Spin down within 6 hours of draw, immediately refrigerate specimen, and freeze specimen within 12 hours of draw.

Useful For

Screening for hepatitis C in primary care settings in high-risk persons with a current or past history of illicit injection drug use or a history of receiving a blood transfusion prior to 1992


Screening for hepatitis C in primary care settings in non-high risk persons born from 1945 through 1965


Note: In accordance with National Coverage Determination guidance, this test is indicated for asymptomatic patients born from 1945 through 1965, those with a history of injection drug use, or a history of receiving blood transfusion prior to 1992.

Testing Algorithm

If hepatitis C virus (HCV) antibody screen is reactive, then HCV RNA by RT-PCR will be performed at an additional charge.


See Hepatitis C: Testing Algorithm for Screening and Diagnosis in Special Instructions.

Method Name

Chemiluminescence Immunoassay

Reporting Name

HCV Ab Scrn w/Reflex to HCV PCR, S

Specimen Type

Serum SST

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum SST Frozen (preferred) 30 days
  Refrigerated  5 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross reject


Heparinized specimen or red-top tube

Reference Values


See Viral Hepatitis Serologic Profiles in Special Instructions.

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.-12:30 a.m.

Saturday; 8 a.m.-4:30 p.m.

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86803 and G0472-Hepatitis C antibody screen

87522-Hepatitis C, quantification (if appropriate)


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCSRN HCV Ab Scrn w/Reflex to HCV PCR, S In Process


Result ID Test Result Name Result LOINC Value
HCVA5 HCV Ab Screen, S 13955-0

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HCVQN HCV RNA Detect/Quant, S Yes No