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Test Code HIVQRM HIV-1 RNA Quantification with Reflex to HIV-1 Genotypic Drug Resistance, Plasma

Additional Codes








Useful For

Detecting and quantifying plasma HIV-1 RNA levels (viral load) in HIV-1-infected patients, followed by genotypic determination of viral resistance to anti-HIV drugs


Guiding initiation or change of antiretroviral treatment regimens

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HIVPR HIV-1 Genotypic PR-RT Resistance, P Yes No

Testing Algorithm

If HIV-1 RNA titer (HIVDQ / HIV-1 RNA Detection and Quantification, Plasma) is 500 copies/mL or higher, then HIV-1 genotypic drug resistance mutations (HIVPR / HIV-1 Genotypic Protease and Reverse Transcriptase Inhibitor Drug Resistance, Plasma) will be performed at an additional charge.


See HIV Treatment Monitoring Algorithm in Special Instructions.

Special Instructions

Method Name

Real Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR)

Reporting Name

HIV-1 RNA reflex to Genotyp Resist, P

Specimen Type

Plasma EDTA

Advisory Information

This test is appropriate for detection and diagnosis of HIV-1 infections, including in children younger than 18 months of age, when serologic tests are not useful (due to presence of maternal HIV antibodies).

Shipping Instructions

1. Freeze plasma specimen immediately, and ship specimen frozen on dry ice.

2. If shipment will be delayed for >24 hours, freeze plasma specimen at -70° C (up to 35 days) until shipment on dry ice.

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Spin down and remove plasma from cells within 6 hours of draw.

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen (preferred) 35 days
  Refrigerated  5 days

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK




Green-top (heparin) tube

Reference Values


Day(s) and Time(s) Performed

HIV-1 quantification: Monday through Saturday; 7 a.m.-4 p.m.

HIV-1 genotyping: varies; test will be performed in batches of 10 specimens

Analytic Time

Monday through Thursday, 1 day; Friday and Saturday, 3 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

87536-HIV-1, quantification

87901-HIV-1 genotypic drug resistance (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIVQG HIV-1 RNA reflex to Genotyp Resist, P 70241-5


Result ID Test Result Name Result LOINC Value
36932 HIV-1 RNA Detect/Quant, P 70241-5

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.