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Test Code MGEP Myasthenia Gravis (MG) Evaluation, Pediatric

Additional Codes

 

MAYO Test ID

MGP1

EPIC Test ID

LAB2621

 

Useful For

Recommended for initial investigation of patients presenting at less than age 20 with a defect of neuromuscular transmission

 

Confirming that a recently acquired neurological disorder has an autoimmune basis

 

Distinguishing acquired myasthenia gravis from congenital myasthenic syndromes (persistently seronegative)

 

Providing a quantitative baseline for future comparisons in monitoring clinical course and response to immunomodulatory treatment

Profile Information

Test ID Reporting Name Available Separately Always Performed
MGEPI MG Pediatric Interpretation, S No Yes
ARBI ACh Receptor (Muscle) Binding Ab Yes Yes
ARMO ACh Receptor (Muscle) Modulating Ab No Yes

Testing Algorithm

See Myasthenia Gravis: Pediatric Diagnostic Algorithm in Special Instructions.

Method Name

Radioimmunoassay (RIA)

Reporting Name

MG Eval, Pediatric

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 2 mL

Additional Information: Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.


Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross reject

Other

NA

Reference Values

ACh RECEPTOR (MUSCLE) BINDING ANTIBODY

≤0.02 nmol/L

 

ACh RECEPTOR (MUSCLE) MODULATING ANTIBODIES

0-20% (reported as __% loss of AChR)

Day(s) and Time(s) Performed

ACh receptor (muscle) binding antibody: Monday through Friday 11 a.m., 6 p.m., and 10 p.m.; Saturday 6 a.m.; Sunday 6 a.m. and 10 a.m.

ACh receptor (muscle) modulating antibodies: Monday through Thursday; 2 p.m., Saturday; 8 a.m.

Analytic Time

3 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

See individual components

CPT Code Information

83519-ACh receptor (muscle) binding antibody

83519-ACh receptor (muscle) modulating antibodies

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MGP1 MG Eval, Pediatric 53705-0

 

Result ID Test Result Name Result LOINC Value
8338 ACh Receptor (Muscle) Binding Ab 11034-6
8879 ACh Receptor (Muscle) Modulating Ab 30192-9
34275 MG Pediatric Interpretation, S 69048-7

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)