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Test Code MISCLM Beta-2 Transferrin: Detection of Spinal Fluid in Other Body Fluid

Additional Codes



Reporting Name

Beta-2 Transferrin, BF

Useful For

Detection of spinal fluid in body fluids, such as ear or nasal fluid

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Body Fluid

Additional Testing Requirements

If specimens are collected from multiple sites on the body (ie, left and right), each specimen must be sent under a separate order.

Necessary Information

Indicate specimen source. Include whether the source is from the right or left side of the body, if applicable.

Specimen Required

Specimen Type: Body fluid

Sources: Nasal, otic, wound, etc


Preferred: Sterile container, syringe, test tube, or microtube

Acceptable: Plain cotton swab or gauze

Specimen Volume: 0.5 mL

Collection Instructions:

1. If submitting a syringe, remove needle. Add cap to end of syringe.

2. If direct collection is not feasible, specimen may be collected using a plain cotton swab or gauze.

3. If gauze is used to collect specimen, circle area on the gauze where specimen was collected.

4. Place cotton swab or gauze in as small a container as possible (eg, plain test tube or collection container).

5. Do not collect specimen with a culture swab.

6. Do not add any liquid to the swab or gauze.

Additional Information:

1. Samples collected from above the shoulders risk salivary contamination, which can degrade the beta-2 transferrin protein. These samples should be frozen immediately following collection and kept frozen until testing is performed.

2. Although results may be obtainable on smaller specimens (perhaps as little as 0.05 mL, depending on the protein concentrations and percentage of spinal fluid in the specimen), reliable results are best obtained with an adequate specimen volume.

3. Samples collected with additives such as microbiology media (eg, Stuart or Amies liquid medium) or TransFix/EDTA (used for analyses in flow cytometry) yield uninterpretable results and will be rejected.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Body Fluid Frozen (preferred)

Reference Values

Negative, no beta-2 transferrin (spinal fluid) detected

Day(s) and Time(s) Performed

Monday through Saturday; 1 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
BETA2 Beta-2 Transferrin, BF 13876-8


Result ID Test Result Name Result LOINC Value
80351 Beta-2 Transferrin, BF 13876-8

Analytic Time

1 day

Reject Due To








Samples stored in storage tubes with TransFix/EDTA


Method Name