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Test Code MISCLM Thiopurine Methyltransferase (TPMT) and Nudix Hydrolase (NUDT15) Genotyping

Additional Codes

 

MAYO Test ID

TPNUV

EPIC Test ID

LAB2608

 


Advisory Information


For TPMT enzyme activity testing, order TPMT3 / Thiopurine Methyltransferase (TPMT) Activity Profile, Erythrocytes.



Specimen Required


Multiple genotype tests can be performed on a single specimen after a single extraction. See Multiple Genotype Test List in Special Instructions for a list of tests that can be ordered together.

 

Submit only 1 of the following specimens:

 

Specimen Type: Whole blood

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days

 

Specimen Type: Saliva

Patient Preparation: Patient should not eat, drink smoke, or chew gum 30 minutes prior to collection.

Supplies: Saliva Swab Collection Kit (T786)

Specimen Volume: One swab

Collection Instructions: Collect and send specimen per kit instructions.

Specimen Stability Information: Ambient 30 days

 

Specimen Type: DNA

Container/Tube: 2 mL screw top tube

Specimen Volume: 100 mcL

Collection Instructions:

1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.

2. Include concentration and volume on tube.

Specimen Stability Information: Frozen (preferred)/Ambient/Refrigerated


Forms

New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

Useful For

Predicting potential for toxicity to thiopurine drugs (6-mercaptopurine, 6-thioguanine, and azathioprine)

Method Name

Real-Time Polymerase Chain Reaction (PCR) With Allelic Discrimination Analysis

Reporting Name

TPMT and NUDT15 Genotype

Specimen Type

Varies

Specimen Minimum Volume

Blood: 0.4 mL
Saliva: 1 swab

Specimen Stability Information

Specimen Type Temperature Time
Varies Varies

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Reference Values

An interpretive report is provided.

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.

Analytic Time

1 day (not reported on Saturday or Sunday)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81401-TPMT

81479-NUDT15

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TPNUV TPMT and NUDT15 Genotype In Process

 

Result ID Test Result Name Result LOINC Value
BA0211 TPMT Genotype In Process
BA0212 TPMT Phenotype 79713-4
BA0213 NUDT15 Genotype In Process
BA0214 NUDT15 Phenotype In Process
BA0215 Interpretation In Process
BA0216 Additional Information In Process
BA0217 Method 49549-9
BA0218 Disclaimer 62364-5
BA0219 Reviewed by In Process