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Test Code MISCLM Porphyrins, Quantitative, Random, Urine

Additional Codes

 

MAYO Test ID

PQNRU

EPIC Test ID

LAB2608

 

Reporting Name

Porphyrins, QN, Random, U

Useful For

Preferred test during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when the specimen will be received at Mayo Medical Laboratories within 72 hours of collection (if it will be longer, PQNU / Porphyrins, Quantitative, 24 Hour, Urine should be ordered)

 

Preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda

Testing Algorithm

The following algorithms are available in Special Instructions:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Method Name

High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection

Includes quantitation of coproporphyrins, uroporphyrins, and intermediate porphyrins (heptacarboxyl, hexacarboxyl, and pentacarboxyl).

Includes liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of porphobilinogen.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Urine


Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Container/Tube: Amber, 60-mL urine bottle (T596)

Specimen Volume: 20-50 mL

Collection Instructions:

1. Patient should abstain from alcohol for 24 hours prior to collection.

2. Collect a random urine specimen.

3. Protect specimen from light.


Specimen Minimum Volume

15 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen 72 hours

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

Specimen not protected from light, pH <5.0

 

Reference Values

UROPORPHYRINS (OCTACARBOXYL)

≤30 nmol/L

 

HEPTACARBOXYLPORPHYRINS

≤7 nmol/L

 

HEXACARBOXYLPORPHYRINS

≤2 nmol/L

 

PENTACARBOXYLPORPHYRINS

≤5 nmol/L

 

COPROPORPHYRINS (TETRACARBOXYL)

≤110 nmol/L

 

PORPHOBILINOGEN

≤1.3 mcmol/L

Day(s) and Time(s) Performed

Monday through Friday; 7 a.m.

CPT Code Information

84110-Porphobilinogen, quantitative

84120-Porphyrins, quantitation and fractionation

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PQNRU Porphyrins, QN, Random, U In Process

 

Result ID Test Result Name Result LOINC Value
32332 Uroporphyrin, Octa 25166-0
32333 Heptacarboxylporphyrins 34314-5
32334 Hexacarboxylporphyrins In Process
32335 Pentacarboxylporphyrins 34352-5
32336 Coproporphyrin, Tetra 25167-8
32337 Porphobilinogen 2811-8
32338 Interpretation 59462-2

Analytic Time

2 days (not reported Saturday or Sunday)

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.