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Test Code MISCLM BRAF Mutation Analysis (V600), Melanoma

Additional Codes

MAYO Test ID
BRAFC
EPIC Test ID
LAB2608

 

Useful For

Identification of melanoma tumors that may respond to BRAF-targeted therapies

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge.

Method Name

Polymerase Chain Reaction (PCR) Analysis

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name

BRAF Mutation AnalysisV600 Melanoma

Specimen Type

Varies


Specimen Required


Pathology report must accompany specimen in order for testing to be performed.

 

Forms: If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen

(http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)

 

Preferred:

Specimen Type: Tissue

Container/Tube: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block.

 

Acceptable:

Specimen Type: Tissue

Container/Tube: Slides

Specimen Volume: 1 stained and 5 unstained

Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 5 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue.


Specimen Minimum Volume

Formalin-fixed, paraffin-embedded (FFPE) tissue block (preferred) or 1 slide stained with hematoxylin-and-eosin and 5 unstained, nonbaked slides (5-microns thick sections) of the tumor tissue.

Specimen Stability Information

Specimen Type Temperature Time
Varies Ambient (preferred)
  Frozen 
  Refrigerated 

Reject Due To

Note: No specimen should be rejected. If specimen not received at appropriate temperature or in wrong anticoagulant, include note to laboratory. If questions, contact laboratory.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Analytic Time

5 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

81210-BRAF (v-raf murine sarcoma viral oncogene humolog B1), Melanoma FDA approved Cobas assay

 

Slide Review

88381-Microdissection, manual

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BRAFC BRAF Mutation AnalysisV600 Melanoma In Process

 

Result ID Test Result Name Result LOINC Value
53211 Result Summary 50397-9
53212 Result No LOINC Needed
53213 Interpretation 69047-9
53214 Specimen 31208-2
53215 Source 31208-2
53257 Tissue ID No LOINC Needed
53216 Released By No LOINC Needed