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Test Code MISCLM BRCA1/BRCA2 Genes, Full Gene Analysis

Additional Codes

MAYO Test ID
BRCAZ
EPIC Test ID
LAB2608

 

Useful For

Establishing a diagnosis of hereditary breast and ovarian cancer (HBOC)

 

Identification of familial BRCA1 or BRCA2 mutation to allow for predictive testing in family members

Method Name

Custom Sequence Capture and Targeted Next Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Multiplex Ligation-Dependent Probe Amplification (MLPA)

Reporting Name

BRCA1/BRCA2 Full Gene Analysis

Specimen Type

Varies


Shipping Instructions


Specimen should arrive within 96 hours of collection.



Specimen Required


Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call Mayo Medical Laboratories for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood

Container/Tube:

Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Additional Information:

1. To ensure minimum volume and concentration of DNA is met, the preferred volume of blood must be submitted. Testing may be canceled if DNA requirements are inadequate.

2. Prior Authorization is available for this assay; see Special Instructions. Submit the required form with the specimen.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Refrigerated (preferred)
  Ambient 
  Frozen 

Reject Due To

No specimen should be rejected.

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Performed weekly; Varies

Analytic Time

3 weeks

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81162

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BRCAZ BRCA1/BRCA2 Full Gene Analysis In Process

 

Result ID Test Result Name Result LOINC Value
37802 Result Summary 50397-9
37803 Result In Process
37804 Interpretation In Process
37805 Additional Information 48767-8
37806 Specimen 31208-2
37807 Source 31208-2
37808 Released By No LOINC Needed

Forms

1. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

2. BRCA1/BRCA2 Genes, Full Gene Analysis (BRCAZ) Prior Authorization Ordering Instructions in Special Instructions

3. Molecular Genetics: Inherited Cancer Syndromes Patient Information (T519)