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Test Code MISCLM Celiac Disease Comprehensive Cascade

Additional Codes

MAYO Test ID
CDCOM
EPIC Test ID
LAB2608

 

Reporting Name

Celiac Disease Comprehensive Casc

Useful For

Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease)

 

Comprehensive algorithmic evaluation including HLA typing

Profile Information

Test ID Reporting Name Available Separately Always Performed
IGA Immunoglobulin A (IgA), S Yes Yes
CELI2 HLA-DQ Typing Yes, (Order CELI) Yes
CDCM1 Celiac Disease Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
EMA Endomysial Abs, S (IgA) Yes No
DAGL Gliadin(Deamidated) Ab, IgA, S Yes No
TTGG Tissue Transglutaminase Ab, IgG, S Yes No
DGGL Gliadin(Deamidated) Ab, IgG, S Yes No
TTGA Tissue Transglutaminase Ab, IgA, S Yes No

Testing Algorithm

If IgA is age-specified normal, then tissue transglutaminase (tTG) IgA will be performed at an additional charge.

 

If tTG IgA is equivocal, then endomysial antibodies IgA and deamidated gliadin antibody IgA will be performed at an additional charge.

 

If IgA is greater than or equal to 1.0 mg/dL but lower than age-specified normal, then tTG IgA, tTG IgG, deamidated gliadin IgA, and deamidated gliadin IgG will be performed at an additional charge.

 

If IgA is below detection (less than 1.0 mg/dL), then tTG IgG and deamidated gliadin IgG will be performed at an additional charge.

 

The following algorithms are available in Special Instructions:

-Celiac Disease Comprehensive Cascade

-Celiac Disease Diagnostic Testing Algorithm

-Celiac Disease Gluten-Free Cascade

-Celiac Disease Routine Treatment Monitoring Algorithm

-Celiac Disease Serology Cascade

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum
Whole Blood ACD-B


Specimen Required


Blood and serum are required.

 

Specimen Type: Blood

Container/Tube: Yellow top (ACD [solution B])

Specimen Volume: 6 mL

Collection Instructions: Do not transfer blood to other containers.

 

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL


Specimen Minimum Volume

Blood: 3 mL; Serum: 1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  14 days
Whole Blood ACD-B Refrigerated (preferred)
  Ambient 

Reject Due To

Hemolysis

Mild OK; Gross OK

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

There are no rejection criteria for whole blood ACD-B

Reference Values

IMMUNOGLOBULIN A (IgA)

0-<5 months: 7-37 mg/dL

5-<9 months: 16-50 mg/dL

9-<15 months: 27-66 mg/dL

15-<24 months: 36-79 mg/dL

2-<4 years: 27-246 mg/dL

4-<7 years: 29-256 mg/dL

7-<10 years: 34-274 mg/dL

10-<13 years: 42-295 mg/dL

13-<16 years: 52-319 mg/dL

16-<18 years: 60-337 mg/dL

≥18 years: 61-356 mg/dL

 

HLA-DQ TYPING

Presence of DQ2 or DQ8 alleles associated with celiac disease

Day(s) and Time(s) Performed

IgA: Monday through Saturday; 3 p.m.

HLA-DQ Typing: Monday through Friday; 7:30 a.m.-5 p.m.

tTG IgA: Monday through Saturday; 3 p.m.

Endomysial antibodies: Monday through Friday; 7 a.m.-5 p.m.

Gliadin IgA: Monday through Saturday; 3 p.m.

tTG IgG: Monday through Saturday; 3 p.m.

Gliadin IgG: Monday through Saturday; 3 p.m.

CPT Code Information

82784-IgA

81376 x2-HLA-DQ Typing

83516-Deamidated gliadin IgA (if appropriate)

83516-Deamidated gliadin IgG (if appropriate)

83516-tTG IgA (if appropriate)

83516-tTG IgG (if appropriate)

86255-Endomysial antibodies (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDCOM Celiac Disease Comprehensive Casc In Process

 

Result ID Test Result Name Result LOINC Value
IGA Immunoglobulin A (IgA), S 2458-8
DQA DQ alpha 1 44728-4
28991 Celiac Disease Interpretation 69048-7
DQB DQ beta 1 43291-4
CELIG Celiac gene pairs present? 48767-8

Analytic Time

7 days (Maxium lab time=14 days)

Test Classification

See Individual Components

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request Form (T728) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/gastroenterology-and-hepatology-test-request.pdf)