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Test Code MISCLM Celiac Disease Gluten-Free Cascade

Additional Codes



Reporting Name

Celiac Disease Gluten-Free Cascade

Useful For

Evaluating patients suspected of having celiac disease who are currently (or were recently) on a gluten-free diet

Profile Information

Test ID Reporting Name Available Separately Always Performed
CELI2 HLA-DQ Typing Yes, (Order CELI) Yes
CDGF1 Celiac Disease Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
TTGA Tissue Transglutaminase Ab, IgA, S Yes No
DAGL Gliadin(Deamidated) Ab, IgA, S Yes No
DGGL Gliadin(Deamidated) Ab, IgG, S Yes No
TTGG Tissue Transglutaminase Ab, IgG, S Yes No
IGA Immunoglobulin A (IgA), S Yes No

Testing Algorithm

If HLA-DQ typing is positive or equivocal for DQ2 or DQ8, then IgA, tissue transglutaminase (tTG) IgA and IgG, and deamidated gliadin IgA and IgG will be performed at an additional charge.


The following algorithms are available in Special Instructions:

-Celiac Disease Comprehensive Cascade

-Celiac Disease Diagnostic Testing Algorithm

-Celiac Disease Gluten-Free Cascade

-Celiac Disease Routine Treatment Monitoring Algorithm

-Celiac Disease Serology Cascade

Method Name

CELI2: Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probe (SSO)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Whole Blood ACD-B

Specimen Required

Blood and serum are required.


Specimen Type: Blood

Container/Tube: Yellow top (ACD solution B)

Specimen Volume: 6 mL

Collection Instructions: Do not transfer blood to other containers.



Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL

Specimen Minimum Volume

Blood: 3 mL/Serum 1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  14 days
Whole Blood ACD-B Refrigerated (preferred)

Reject Due To


See individual test IDs


See individual test IDs


See individual test IDs


See individual test IDs

Day(s) and Time(s) Performed

IgA: Monday through Saturday; 3 p.m.

HLA-DQ Typing: Monday through Friday; 7:30 a.m.-5 p.m.

tTG IgA: Monday through Saturday; 3 p.m.

Gliadin IgA: Monday through Saturday; 3 p.m.

Gliadin IgG: Monday through Saturday; 3 p.m.

tTG IgG: Monday through Saturday; 3 p.m.

CPT Code Information

81376 x 2-HLA-DQ typing

82784-IgA (if appropriate)

83516-Deamidated gliadin IgA (if appropriate)

83516-Deamidated gliadin IgG (if appropriate)

83516-tTG IgA (if appropriate)

83516-tTG IgG (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDGF Celiac Disease Gluten-Free Cascade In Process


Result ID Test Result Name Result LOINC Value
DQA DQ alpha 1 44728-4
28991 Celiac Disease Interpretation 69048-7
DQB DQ beta 1 43291-4
CELIG Celiac gene pairs present? 48767-8

Analytic Time

7 days

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.


If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request Form (T728) with the specimen (