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Test Code MISCLM Cortisol, Saliva

Additional Codes

MAYO Test ID
SALCT
EPIC Test ID
LAB2608

 

Reporting Name

Cortisol, Saliva

Useful For

Screening for Cushing syndrome

 

Diagnosis of Cushing syndrome in patients presenting with symptoms or signs suggestive of the disease

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Saliva


Specimen Required


Patient Preparation:

1. Do not brush teeth before collecting specimen.

2. Do not eat or drink for 15 minutes prior to specimen collection.

Supplies: Cortisol, Saliva Collection Kit (T514)

Container/Tube: SARSTEDT Salivette (T514)

Specimen Volume: 1.5 mL

Collection Instructions:

1. Collect specimen between 11 p.m. and midnight, and record collection time.

2. To use the Salivette:

a. Remove top cap of container to expose swab.

b. Place swab directly into mouth by tipping container so swab falls into mouth. Do not touch swab with fingers.

c. Keep swab in mouth for approximately 2 minutes. Roll swab in mouth, do not chew swab.

d. Place swab back into its container without touching, and replace the cap.

3. Record collection time, and send appropriately labeled Salivette to laboratory.

Additional Information:

1. Reference values are also available for 8 a.m. (7 a.m.-9 a.m.) and 4 p.m. (3 p.m.-5 p.m.) collections, however, 11 p.m. to midnight collection is preferred.

2. Indicate collection time.

3. If multiple specimens are collected, submit each vial under a separate order.


Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Saliva Refrigerated (preferred) 7 days
  Frozen  60 days
  Ambient  7 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA

Reference Values

7 a.m.-9 a.m.: 100-750 ng/dL

3 p.m.-5 p.m.: <401 ng/dL

11 p.m.-midnight: <100 ng/dL

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 4 p.m.

CPT Code Information

82533

LOINC Code Information

Result ID Test Result Name Result LOINC Value
84225 Cortisol, Saliva 2142-8
23612 AM Cortisol 58674-3
23613 PM Cortisol 58676-8
23614 Midnight Cortisol 58642-0

Analytic Time

2 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.