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Test Code MISCLM Cryoglobulin, Serum

Additional Codes



Reporting Name

Cryoglobulin, S

Useful For

Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases


Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a result other than negative, then iImmunofixation will be performed at an additional charge. Positive cryoglobulins of ≥0.1 mL of precipitate will be typed once.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of serum from red cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with <3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require draw of a new specimen.

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred)

Reference Values

Negative (positives reported as percent) 

Day(s) and Time(s) Performed

Monday through Friday; 4 pm

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRY_S Cryoglobulin, S In Process


Result ID Test Result Name Result LOINC Value
2684 Cryoglobulin, S 15174-6

Analytic Time

2 days

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross OK


Serum gel tube; plasma gel tube

Method Name

CRY_S: Quantitation and Qualitative Typing Precipitation at 1 Degree C.
Orderable as part of a panel or as a stand alone test. For further information see CRGSP / Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma.

IMFXC: Immunofixation