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Test Code PLABM Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum

Additional Codes

 

MAYO Test ID

CLPMG

EPIC Test ID

LAB464

 

Reporting Name

Phospholip Ab (Cardiolip) IgM/IgG

Useful For

Testing for phospholipid antibodies is indicated in the following clinical situations:

-Unexplained arterial or venous thrombosis

-A history of pregnancy morbidity defined as 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation, 1 or more premature births before 34 weeks of gestation caused by severe preeclampsia or placental insufficiency, or 3 or more unexplained, consecutive spontaneous abortions before the 10th week of gestation with no identifiable maternal hormonal or anatomic, or maternal or paternal chromosomal causes

-Presence of an unexplained cutaneous circulatory disturbance, eg, livido reticularis or pyoderma gangrenosum

-Presence of a systemic rheumatic disease especially lupus erythematosus

-Unexplained thrombocytopenia or hemolytic anemia

-Possible nonbacterial, thrombotic endocarditis

Profile Information

Test ID Reporting Name Available Separately Always Performed
MCLIP Phospholipid Ab IgM, S Yes Yes
GCLIP Phospholipid Ab IgG, S Yes Yes

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

Mild OK; Gross OK

Other

NA

Reference Values

<15.0 MPL or GPL (negative)

15.0-39.9 MPL or GPL (weakly positive)

40.0-79.9 MPL or GPL (positive)

≥80.0 MPL or GPL  (strongly positive)

MPL refers to IgM Phospholipid Units. One MPL unit is 1 microgram of IgM antibody.

GPL refers to IgG Phospholipid Units. One GPL unit is 1 microgram of IgG antibody. 

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Saturday; 4 p.m.

CPT Code Information

86147 x 2

LOINC Code Information

Result ID Test Result Name Result LOINC Value
GCLIP Phospholipid Ab IgG, S 3181-5
MCLIP Phospholipid Ab IgM, S 3182-3

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Analytic Time

Same day/1 day

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf)

Coagulation Test Request Form (T753) (http://www.mayomedicallaboratories.com/it-mmfiles/coagulation-test-request-form.pdf)