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Test Code PRCAM Protein C Activity, Plasma

Additional Codes

 

MAYO Test ID

CFX

EPIC Test ID

LAB489

 

Reporting Name

Protein C Activity, P

Useful For

As an initial test for evaluating patients suspected of having congenital protein C deficiency, including those with personal or family histories of thrombotic events

 

Because coagulation testing and its interpretation is complex, Mayo Medical Laboratories suggests ordering THRMP / Thrombophilia Profile.

 

Detecting and confirming congenital Type I and Type II protein C deficiencies, detecting and confirming congenital homozygous protein C deficiency, and identifying decreased functional protein C of acquired origin (eg, due to oral anticoagulant effect, vitamin K deficiency, liver disease, intravascular coagulation and fibrinolysis/disseminated intravascular coagulation.)

Method Name

Amidolysis of Chromogenic Substrate

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma Na Cit


Specimen Required


See Coagulation Studies in Special Instructions.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Fasting

2. Spin down, remove plasma, and spin plasma again.

3. Freeze specimen immediately at ≤-40° C, if possible.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.

3. If the patient is being treated with Coumadin, this should be noted. Coumadin will lower protein C.

4. Heparin ≥4 U/mL may interfere with this assay.

5. Lipemic specimen may be rejected.

6. Coagulation testing is highly complex, often requiring the performance of multiple assays and correlation with clinical information. For that reason, we suggest ordering THRMP / Thrombophilia Profile.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen 14 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

NA

Other

NA

Special Instructions

Reference Values

Adults: 70%-150%

Normal, full-term newborn infants or healthy premature infants may have decreased levels of protein C activity (15%-50%), which may not reach adult levels until later in childhood or early adolescence.*

*See Pediatric Hemostasis References in Coagulation Studies in Special Instructions.

Day(s) and Time(s) Performed

Monday through Friday

CPT Code Information

85303

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CFX Protein C Activity, P 27818-4

 

Result ID Test Result Name Result LOINC Value
CFX Protein C Activity, P 27818-4

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Analytic Time

1 day