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Test Code PROTCM Protein C Antigen, Plasma

Additional Codes

 

MAYO Test ID

PCAG

EPIC Test ID

LAB490

 

Reporting Name

Protein C Ag, P

Useful For

Differentiating congenital Type I protein C deficiency from Type II deficiency

 

Evaluating the significance of decreased functional protein C, especially when decreased protein C activity might be congenital rather than acquired (eg, due to oral anticoagulant effect, vitamin K deficiency, liver disease, or intravascular coagulation and fibrinolysis/disseminated intravascular coagulation)

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma Na Cit


Specimen Required


See Coagulation Studies in Special Instructions.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Spin down, remove plasma, and spin plasma again.

2. Freeze specimen immediately at ≤-40° C, if possible.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.

3. If the patient is being treated with Coumadin, this should be noted. Coumadin will lower protein C.

4. Coagulation testing is highly complex, often requiring the performance of multiple assays and correlation with clinical information. For that reason, we suggest ordering THRMP / Thrombophilia Profile.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen 14 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

NA

Other

NA

Special Instructions

Reference Values

Adults: 70%-150%

Normal, full-term newborn infants or healthy premature infants may have decreased levels of protein C antigen (15%-50%), which may not reach adult levels until later in childhood or early adolescence.*

*See Pediatric Hemostasis References in Coagulations Studies in Special Instructions.

Day(s) and Time(s) Performed

Monday through Friday; a.m.

CPT Code Information

85302

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PCAG Protein C Ag, P 27820-0

 

Result ID Test Result Name Result LOINC Value
9127 Protein C Ag, P 27820-0

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Analytic Time

1 day