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Test Code RENINM Renin Activity, Plasma

Additional Codes

 

MAYO Test ID

PRA

EPIC Test ID

LAB532

 

Reporting Name

Renin Activity, P

Useful For

Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome)

 

Not useful for determination of plasma renin concentration.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Portions of this test are covered by patents held by Quest Diagnostics

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Plasma EDTA


Specimen Required


Patient Preparation: The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone (Aldactone). Spironolactone should be discontinued for 4 to 6 weeks before testing.

Collection Container/Tube: Chilled, lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Draw blood in a chilled syringe from a patient in a seated position; place specimen in a chilled, lavender-top (EDTA) tube; and mix.

2. Alternatively, draw blood directly in a chilled, lavender top (EDTA) tube.

3. Immediately place EDTA tube into an ice-water bath until thoroughly cooled.

4. Refrigerate specimen during centrifugation and immediately transfer plasma to plastic vial. (If a refrigerated centrifuge is unavailable, chill the centrifuge carriers. Centrifuge specimen for ≤5 minutes, then promptly transfer plasma.)

5. Immediately freeze plasma.

Additional Information: See Renin-Aldosterone Studies in Special Instructions for further information.


Specimen Minimum Volume

1.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 14 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

NA

Special Instructions

Reference Values

0-2 years: 4.6 ng/mL/hour (mean)* Range: 1.4-7.8 ng/mL/hour

3-5 years: 2.5 ng/mL/hour (mean)* Range: 1.5-3.5 ng/mL/hour

6-8 years: 1.4 ng/mL/hour (mean)* Range: 0.8-2.0 ng/mL/hour

9-11 years: 1.9 ng/mL/hour (mean)* Range: 0.9-2.9 ng/mL/hour

12-17 years: 1.8 ng/mL/hour (mean)* Range: 1.2-2.4 ng/mL/hour

Mean data not standardized as to time of day or diet. Infants were supine, children sitting.

 

Na-depleted, upright (peripheral vein specimen)

18-39 years: 10.8 ng/mL/hour (mean)

2.9-24.0 ng/mL/hour (range)

≥40 years: 5.9 ng/mL/hour (mean)

2.9-10.8 ng/mL/hour (range)

 

Na-replete, upright (peripheral vein specimen)

18-39 years: 1.9 ng/mL/hour (mean)

≤0.6-4.3 ng/mL/hour (range)

≥40 years: 1.0 ng/mL/hour (mean)

≤0.6-3.0 ng/mL/hour (range)

*Stalker HP, Holland NH, Kotchen JM, Kotchen TA: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258

Day(s) and Time(s) Performed

Monday through Friday; 1 p.m.

CPT Code Information

84244

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PRA Renin Activity, P 2915-7

 

Result ID Test Result Name Result LOINC Value
8060 Renin Activity, P 2915-7

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Analytic Time

2 days

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf

Cardiovascular Test Request Form (T724) (http://www.mayomedicallaboratories.com/it-mmfiles/cardiovascular-request-form.pdf)