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Test Code TESTGM Testosterone, Total and Free, Serum

Additional Codes

 

MAYO Test ID

TGRP

EPIC Test ID

LAB173

 

Reporting Name

Testosterone, Total and Free, S

Useful For

This assay is the alternative, second-level test for suspected increases or decreases in physiologically active testosterone (preferred: TTBS / Testosterone, Total and Bioavailable, Serum); indications:

-Assessment of androgen status in cases with suspected or known sex hormone-binding globulin-binding abnormalities

-Assessment of functional circulating testosterone in early pubertal boys and older men

-Assessment of functional circulating testosterone in women with symptoms or signs of hyperandrogenism, but normal total testosterone levels

-Monitoring of testosterone therapy or antiandrogen therapy in older men and in females

Profile Information

Test ID Reporting Name Available Separately Always Performed
FRTST Testosterone, Free, S No Yes
TTST Testosterone, Total, S Yes Yes

Method Name

FRTST: Equilibrium Dialysis

TTST: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 2.5 mL

Additional Information: Patient's age and sex are required.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  60 days

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

Mild OK; Gross OK

Other

NA

Reference Values

TESTOSTERONE, FREE

Males (adult):

20 - <25 years: 5.25-20.7 ng/dL

25 - <30 years: 5.05-19.8 ng/dL

30 - <35 years: 4.85-19.0 ng/dL

35 - <40 years: 4.65-18.1 ng/dL

40 - <45 years: 4.46-17.1 ng/dL

45 - <50 years: 4.26-16.4 ng/dL

50 - <55 years: 4.06-15.6 ng/dL

55 - <60 years: 3.87-14.7 ng/dL

60 - <65 years: 3.67-13.9 ng/dL

65 - <70 years: 3.47-13.0 ng/dL

70 - <75 years: 3.28-12.2 ng/dL

75 - <80 years: 3.08-11.3 ng/dL

80 - <85 years: 2.88-10.5 ng/dL

85 - <90 years: 2.69-9.61 ng/dL

90 - <95 years: 2.49-8.76 ng/dL

95-100+ years: 2.29-7.91 ng/dL

 

Males (children):

<1 year: Term infants

 

1 to 15 days: 0.20-3.10 ng/dL*

16 days to 1 year: Values decrease gradually from newborn (0.20-3.10 ng/dL) to prepubertal levels

*Citation: J Clin Endocrinol Metab 1973;36(6):1132-1142

 

1-8 years: <0.04-0.11 ng/dL

9 years: <0.04-0.45 ng/dL

10 years: <0.04-1.26 ng/dL

11 years: <0.04-5.52 ng/dL

12 years: <0.04-9.28 ng/dL

13 years: <0.04-12.6 ng/dL

14 years: 0.48-15.3 ng/dL

15 years: 1.62-17.7 ng/dL

16 years: 2.93-19.5 ng/dL

17 years: 4.28-20.9 ng/dL

18 years: 5.40-21.8 ng/dL

19 years: 5.36-21.2 ng/dL

 

Females (adult):

20 - <25 years: 0.06-1.08 ng/dL

25 - <30 years: 0.06-1.06 ng/dL

30 - <35 years: 0.06-1.03 ng/dL

35 - <40 years: 0.06-1.00 ng/dL

40 - <45 years: 0.06-0.98 ng/dL

45 - <50 years: 0.06-0.95 ng/dL

50 - <55 years: 0.06-0.92 ng/dL

55 - <60 years: 0.06-0.90 ng/dL

60 - <65 years: 0.06-0.87 ng/dL

65 - <70 years: 0.06-0.84 ng/dL

70 - <75 years: 0.06-0.82 ng/dL

75 - <80 years: 0.06-0.79 ng/dL

80 - <85 years: 0.06-0.76 ng/dL

85 - <90 years: 0.06-0.73 ng/dL

90 - <95 years: 0.06-0.71 ng/dL

95-100+ years: 0.06-0.68 ng/dL

 

Females (children):

<1 year: Term infants

 

1 to 15 days: 0.06-0.25 ng/dL*

16 days to 1 year: Values decrease gradually from newborn (0.06-0.25 ng/dL) to prepubertal levels

*Citation: J Clin Endocrinol Metab, 36(6):1132-1142, 1973

 

1-4 years: <0.04 ng/dL

5 years: <0.04-0.07 ng/dL

6 years: <0.04-0.14 ng/dL

7 years: <0.04-0.23 ng/dL

8 years: <0.04-0.34 ng/dL

9 years: <0.04-0.46 ng/dL

10 years: <0.04-0.59 ng/dL

11 years: <0.04-0.72 ng/dL

12 years: <0.04-0.84 ng/dL

13 years: <0.04-0.96 ng/dL

14 years: <0.04-1.06 ng/dL

15-18 years: <0.04-1.09 ng/dL

19 years: 0.06-1.08 ng/dL

 

TESTOSTERONE, TOTAL

Males        

0-5 months: 75-400 ng/dL

6 months-9 years: <7-20 ng/dL

10-11 years: <7-130 ng/dL

12-13 years: <7-800 ng/dL

14 years: <7-1,200 ng/dL

15-16 years: 100-1,200 ng/dL

17-18 years: 300-1,200 ng/dL

≥19 years: 240-950 ng/dL      

Tanner Stages* 

I (prepubertal): <7-20

II: 8-66

III: 26-800

IV: 85-1,200      

V (young adult): 300-950

 

Females           

0-5 months: 20-80 ng/dL

6 months-9 years: <7-20 ng/dL

10-11 years: <7-44 ng/dL

12-16 years: <7-75 ng/dL

17-18 years: 20-75 ng/dL

≥19 years: 8-60 ng/dL

Tanner Stages*

I (prepubertal): <7-20

II: <7-47

III: 17-75

IV: 20-75

V (young adult): 12-60

 

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years and for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. For boys, there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.

Day(s) and Time(s) Performed

Monday through Friday; 2 p.m. Saturday and Sunday; Varies

CPT Code Information

84402-Testosterone, free

84403-Total     

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TGRP Testosterone, Total and Free, S 58952-3

 

Result ID Test Result Name Result LOINC Value
3631 Testosterone, Free, S 2991-8
8533 Testosterone, Total, S 2986-8

Analytic Time

3 days

Forms

If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf).