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Test Code VANCT Vancomycin, Trough, LAB39

Performing Laboratory

St. Luke's Hospital Cedar Rapids

Specimen Requirements

Container/Tube:

Preferred: Green-top (lithium heparin) tube

Acceptable: Gold-top serum gel tube or plain red-top tube

Specimen Volume: 0.2 mL of plasma or serum

Stability: Separated specimens should be analyzed immediately or kept at 2 – 8 °C and

               analyzed within 72 hours. For longer storage, samples may be frozen at -20 °C for

               up to 6 months.

Collection Instructions: Trough level should be drawn immediately prior to next dose.

Note: 1. Vancomycin time to steady state is after 20 to 30 hours of chronic dosing.

 

Reference Values

Therapeutic range: 5-15 mcg/mL

Critical value: >15 mcg/mL

Useful For

Vancomycin is a glycopeptide antibiotic, which is bactericidal against many gram-positive and some gram-negative cocci. It is useful in therapy of severe staphylococcal (including methicillin-resistant staphylococci) infections in patients who cannot receive or who have failed to respond to the penicillins and cephalosporins.

 

Peak serum levels of vancomycin in the range of 30 to 40 mg/mL, and trough blood levels of 5 to 10 mg/mL are suggested for optimal therapeutic effectiveness. In the presence of impaired renal function, unnecessarily high blood levels of vancomycin (approximately 90 mg/mL) may damage the eighth cranial nerve and cause deafness.

Day(s) Test Set Up

Monday through Sunday

Methodology

Turbidimetric Inhibition Immunoassay

Test Classification and CPT Coding

80202