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Test Code CDSPM Celiac Disease Serology Cascade

Additional Codes



Reporting Name

Celiac Disease Serology Cascade

Useful For

Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease, positivity for DQ2 and/or DQ8)

Profile Information

Test ID Reporting Name Available Separately Always Performed
IGA Immunoglobulin A (IgA), S Yes Yes
CDSP1 Celiac Disease Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
EMA Endomysial Abs, S (IgA) Yes No
DAGL Gliadin(Deamidated) Ab, IgA, S Yes No
TTGG Tissue Transglutaminase Ab, IgG, S Yes No
DGGL Gliadin(Deamidated) Ab, IgG, S Yes No
TTGA Tissue Transglutaminase Ab, IgA, S Yes No

Testing Algorithm

If IgA is age-specified normal, then tissue transglutaminase (tTG) IgA will be performed at an additional charge.


If tTG IgA is equivocal, then endomysial antibodies IgA and deamidated gliadin antibody IgA will be performed at an additional charge.


If IgA is greater or equal to 1.0 mg/dL, but lower than age-specified normal, then tTG IgA, tTG IgG, deamidated gliadin IgA, and deamidated gliadin IgG will be performed at an additional charge.


If IgA is below detection (<1.0 mg/dL), then tTG IgG and deamidated gliadin IgG will be performed at an additional charge.


The following algorithms are available in Special Instructions:

-Celiac Disease Comprehensive Cascade

-Celiac Disease Diagnostic Testing Algorithm

-Celiac Disease Gluten-Free Cascade

-Celiac Disease Routine Treatment Monitoring Algorithm

-Celiac Disease Serology Cascade

Method Name


Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Advisory Information

This cascade should not be used in patients who have previously been or are currently being treated with a gluten-free diet. For these individuals, CDGF / Celiac Disease Gluten-Free Cascade should be ordered.


This cascade should not be used in individual who are negative for DQ2 and DQ8, as a diagnosis of celiac disease is unlikely. For individuals who are positive for either DQ2 and/or DQ8, this test may be ordered to assess the levels of autoantibodies associated with celiac disease.

Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL

Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  14 days

Reject Due To


Mild OK; Gross Rejects


Mild OK; Gross Reject


Mild OK; Gross OK



Reference Values

Immunoglobulin A

0-<5 months: 7-37 mg/dL

5-<9 months: 16-50 mg/dL

9-<15 months: 27-66 mg/dL

15-<24 months: 36-79 mg/dL

2-<4 years: 27-246 mg/dL

4-<7 years: 29-256 mg/dL

7-<10 years: 34-274 mg/dL

10-<13 years: 42-295 mg/dL

13-<16 years: 52-319 mg/dL

16-<18 years: 60-337 mg/dL

≥18 years: 61-356 mg/dL

CPT Code Information


83516-Deamidated gliadin IgA (if appropriate)

83516-Deamidated gliadin IgG (if appropriate)

83516-tTG IgA (if appropriate)

83516-tTG IgG (if appropriate)

86255-Endomysial antibodies (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDSP Celiac Disease Serology Cascade In Process


Result ID Test Result Name Result LOINC Value
IGA Immunoglobulin A (IgA), S 2458-8
28991 Celiac Disease Interpretation 69048-7

Analytic Time

7 days

Test Classification

See Individual Test IDs


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

General Request Form (T239) (

Gastroenterology and Hepatology Test Request Form (T728) (