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Test Code CNSA Central Nervous System Consultation, Autopsy

Shipping Instructions

Ship specimen using the Central Nervous System Consult Kit (T633).

Necessary Information

It is imperative that detailed clinical information and, when possible, operative notes and radiographs accompany the specimen.

Specimen Required

Hematoxylin-and-eosin stained sections are also acceptable, but must be accompanied by paraffin blocks and/or remaining wet tissue.


In cases submitted as part of a research protocol, please contact 507-284-3887 for further guidance.


Supplies: Central Nervous System Consult Kit (T633)

Sources: Brain (and spinal cord when indicated)

Container/Tube: Plastic container

Specimen Volume: 1 cm(3) cube

Collection Instructions:

1. Take a small (1 cm[3]) cube of brain from 1 of the frontal lobes (typically, right inferior frontal).

2. Wrap in aluminum foil and place in plastic container.

3. Label container with identifying information (ie, patient name, date of birth, autopsy number, and date of collection).

4. Freeze and store in a -70° C freezer.

5. Place the remaining brain in 10% formalin if non-CJD, and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.

Additional Information: Upon completion of consultation, the brain tissue will be stored indefinitely in the Mayo Clinic Tissue Registry. The Mayo Clinic policy precludes our evaluation of cases under litigation that involve non-Mayo Clinic patients.


1. If not ordering electronically, complete, print, and send a Pathology Test Request Form (T246) with the specimen (

2. Submitting Non-Protocol Autopsy Brain/Spinal Cord for Examination or Submitting Brain for Neuropathologic Examination-Cases Suspected of Creutzfeldt-Jakob Disease (CJD) in Special Instructions.

Useful For

Evaluation of congenital neurological disease


Evaluation of neurodegenerative disease


Evaluation of cases with a complex neurological or neurosurgical history


Evaluation of sudden unexplained death


Not for cases under litigation without preauthorization

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
NERPC Necropsy, regional No No
NESPC Necropsy, single organ No No

Testing Algorithm

When only a brain is submitted, NERPC / Necropsy, regional will be charged.

When both a brain and spinal cord are submitted, NESPC / Necropsy, single organ will be charged.

Method Name

Includes hematoxylin and eosin stains. Additional special stains or procedures necessary for diagnosis will be billed separately.

Reporting Name

Neuropathology Consult

Specimen Type


Specimen Minimum Volume

Entire collection

Specimen Stability Information

Specimen Type Temperature Time
Varies Ambient (preferred)

Reject Due To

No specimen should be rejected.

Reference Values

This request will be processed as a consultation. Appropriate dissection will be performed and an interpretive report provided.

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

30 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

88037 (if appropriate)

88036 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CNSA Neuropathology Consult In Process


Result ID Test Result Name Result LOINC Value
71070 Interpretation In Process
71071 Participated in the Interpretation No LOINC Needed
71072 Report electronically signed by 19139-5
71073 Addendum 35265-8
71074 Gross Description 22634-0
71075 Material Received 81178-6
71589 Disclaimer 62364-5
71795 Case Number 80398-1