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Test Code HCSRN Hepatitis C Antibody Screen with Reflex to HCV RNA by PCR, Serum

Advisory Information

This test is not intended for testing symptomatic individuals (ie, diagnostic purposes). For testing such patients with or without risk factors for hepatitis C virus (HCV) infection, order HCVDX / Hepatitis C Antibody with Reflex to HCV RNA by PCR, Serum.

Shipping Instructions

If shipment will be delayed for more than 24 hours, freeze serum at -70° C until shipment on dry ice.

Specimen Required

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions.

2. Pour off serum into aliquot tube.

Useful For

Screening for hepatitis C in primary care settings in high-risk persons with a current or past history of illicit injection drug use or a history of receiving a blood transfusion prior to 1992


Screening for hepatitis C in primary care settings in non-high risk persons born from 1945 through 1965


Note: In accordance with National Coverage Determination guidance, this test is indicated for asymptomatic patients born from 1945 through 1965, those with a history of injection drug use, or a history of receiving blood transfusion prior to 1992.

Testing Algorithm

If hepatitis C virus (HCV) antibody screen is reactive, then HCV RNA by RT-PCR will be performed at an additional charge.


See Hepatitis C: Testing Algorithm for Screening and Diagnosis in Special Instructions.

Method Name

Chemiluminescence Immunoassay

Reporting Name

HCV Ab Scrn w/Reflex to HCV PCR, S

Specimen Type

Serum SST

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum SST Frozen (preferred) 30 days
  Refrigerated  5 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross reject


Heparinized specimen or red-top tube

Reference Values


See Viral Hepatitis Serologic Profiles in Special Instructions.

Day(s) and Time(s) Performed

Monday through Saturday; Varies

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86803 and G0472

87522 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCSRN HCV Ab Scrn w/Reflex to HCV PCR, S 13955-0


Result ID Test Result Name Result LOINC Value
HCVA5 HCV Ab Screen, S 13955-0

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HCVQN HCV RNA Detect/Quant, S Yes No