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Test Code MISCLM HIV-1 and HIV-2 Antigen and Antibody Evaluation, Serum

Additional Codes









Useful For

Screening for HIV-1 and/or HIV-2 infection in asymptomatic patients


Diagnosing HIV-1 and/or HIV-2 infection in symptomatic patients


Follow-up testing of individuals with reactive results from rapid HIV tests

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HIVDI HIV Ab Confirm / Differentiation, S Yes No

Testing Algorithm

This test begins with HIV-1/-2 antigen and antibody screen by the chemiluminescence immunoassay method. If HIV-1/-2 screen result is reactive, then HIV-1/-2 antibody differentiation test (by immunochromatographic method) is performed at an additional charge. 


See HIV Testing Algorithm (Fourth Generation Screening Assay) Including Follow-up of Reactive HIV Rapid Serologic Test Results in Special Instructions.

Reporting Name

HIV-1/-2 Ag and Ab Screen, S

Specimen Type


Advisory Information

Autopsy specimens or cadaver blood sources are not acceptable for this test. The FDA-licensed assay for autopsy or cadaver blood sources is HV1CD / HIV-1 and HIV-2 Antibodies for Cadaveric or Hemolyzed Specimens, Serum.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Spin down and remove serum from clot within 24 hours.

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  30 days
  Ambient  36 hours

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK: Gross reject


Autopsy or cadaver blood specimens

Reference Values


Day(s) and Time(s) Performed

Monday through Saturday; Varies

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


G0475 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIVCO HIV-1/-2 Ag and Ab Screen, S 56888-1


Result ID Test Result Name Result LOINC Value
HIVC1 HIV-1/-2 Ag and Ab Screen, S 56888-1

Method Name

Chemiluminescent Microparticle Immunoassay