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Test Code PSA,PSASCR Prostate Specific Antigen (PSA), Serum

Additional Codes


LAB2683, Prostate Specific Antigen Medicare Screen

Useful For

PSA is detected in the serum of males with normal, benign hypertrophic, and malignant prostate tissue.  PSA is not detected in the serum of males without prostate tissue (because of radical prostatectomy or cystroprostatectomy) or in the serum of most females.  The fact that PSA is unique to prostate tissue makes it a suitable marker for monitoring men with cancer of the prostate.  PSA is also useful for determining possible recurrence after therapy when used in conjunction with other diagnostic indices.


Chemiluminescence/Two-Site Immunoenzymatic Sandwich Assay, WHO-Standardized

Performing Laboratory

St. Luke's Hospital Cedar Rapids

Specimen Requirements

Container/Tube: Gold-top serum gel tube or plain, red-top tube-Plasma is not acceptable.
Specimen: 0.5 mL, minimum volume 0.1 mL of serum

Stability:  8 hours at room temperature.  Store and transport refrigerated for 48 hours.  Stable 6 months if frozen.

Collection Instructions: Specimen for PSA testing should be drawn prior to such prostatic manipulations as digital rectal exam (DRE), prostatic massage, transrectal ultrasound, and prostatic biopsy.


Note: 1. DRE may cause a transient increase in serum PSA levels. A repeat PSA measurement in the case of borderline elevation has been recommended. Transrectal needle biopsy has also been shown to cause persisting PSA elevations, thus a 6 week waiting period between needle biopsy and PSA sampling has been recommended.

2. Human anti-mouse antibodies or other heterophile antibodies may be present in patient specimens. This assay has been specially formulated to minimize the effects of these antibodies, however results from patients known to have these antibodies should be carefully evaluated.

Reference Values

0.0-4.0 ng/mL

Day(s) Test Set Up

Monday through Sunday

Test Classification and CPT Coding