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Test Code AMTNOM Amitriptyline and Nortriptyline, Serum

Additional Codes

 

MAYO Test ID

AMTRP

EPIC Test ID

LAB681

 

Useful For

Monitoring amitriptyline and nortriptyline serum concentrations during therapy

 

Evaluating potential amitriptyline and nortriptyline toxicity

 

May aid in evaluating patient compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Amitriptyline and Nortriptyline, S

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose (minimum 12 hours after last dose).

2. Centrifuge and aliquot serum into a plastic vial. Serum must be separated from cells within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Amitriptyline and nortriptyline

Total therapeutic concentration: 80-200 ng/mL

 

Nortriptyline

Therapeutic concentration: 70-170 ng/mL

Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Day(s) Performed

Tuesday, Thursday, Sunday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AMTRP Amitriptyline and Nortriptyline, S 43106-4

 

Result ID Test Result Name Result LOINC Value
63506 Amitriptyline 3333-2
36755 Nortriptyline 3872-9
36756 Amitriptyline and Nortriptyline 3335-7

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.