Sign in →

Test Code CZPSM Clonazepam and 7-Aminoclonazepam, Serum

Additional Codes



Useful For

Assessing compliance


Monitoring for appropriate therapeutic level


Assessing toxicity

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Clonazepam and 7-Aminoclonazepam, S

Specimen Type

Serum Red

Specimen Required

Container/Tube: Red top

Specimen Volume: 1.2 mL

Collection Instructions:

1. Draw specimen immediately before next scheduled dose (minimum 12 hours after last dose).

2. Serum must be separated from cells within 2 hours of draw.

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To


Mild OK; Gross OK


Mild OK; Gross OK


Mild OK; Gross reject


Serum gel tube

Reference Values


Anticonvulsant: 20-70 ng/mL

Anxiolytic: 4-80 ng/mL

Some individuals may show therapeutic response outside of these ranges, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 

Note: Therapeutic ranges are for specimens drawn at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Day(s) and Time(s) Performed

Tuesday, Thursday; 1 a.m.

Analytic Time

2 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80346 and G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CZPS Clonazepam and 7-Aminoclonazepam, S In Process


Result ID Test Result Name Result LOINC Value
65044 Clonazepam 3494-2
41782 7-Aminoclonazepam 28059-4