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Test Code MISCLM Ceramides, Plasma

Additional Codes



Useful For

Evaluation for risk of major adverse events due to cardiovascular disease within the next 1 to 5 years

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Ceramides, P

Specimen Type

Plasma EDTA

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge, aliquot at least 1 mL plasma and freeze within 8 hours.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen (preferred) 30 days
  Refrigerated  24 hours
  Ambient  8 hours

Reject Due To


Mild OK; Moderate reject


Mild OK; Gross OK


Mild OK; Gross OK



Reference Values

Ceramide (16:0): 0.19-0.36 mcmol/L

Ceramide (18:0): 0.05-0.14 mcmol/L

Ceramide (24:1): 0.65-1.65 mcmol/L

Ceramide (16:0)/(24:0): <0.11

Ceramide (18:0)/(24:0): <0.05

Ceramide (24:1)/(24:0): <0.45

Ceramide Risk Score:

0-2 Lower risk

3-6 Moderate risk

7-9 Increased risk

10-12 Higher risk


Reference values have not been established for patients who are <18 years of age.


Note: Ceramide (24:0) alone has not been independently associated with disease and will not be reported.

Day(s) and Time(s) Performed

Tuesday; 9 a.m.

Analytic Time

2 days

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CERAM Ceramides, P In Process


Result ID Test Result Name Result LOINC Value
42428 Ceramide (16:0) In Process
42429 Ceramide (18:0) In Process
42430 Ceramide (24:1) In Process
42431 Ceramide (16:0)/(24:0) ratio In Process
42432 Ceramide (18:0)/(24:0) ratio In Process
42433 Ceramide (24:1)/(24:0) ratio In Process
42434 Ceramide Score In Process


If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (