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Test Code PBNP Pro B-Type Natriuretic Peptide, LAB2670

Performing Laboratory

St.  Luke's Hospital Cedar Rapids

Specimen Requirements

Preferred Container/Tube: Mint green-top (heparin) tube

Acceptable Container/Tube:  Green-top (heparin) tube, lavender-top (EDTA) tube, red-top or gold-top (SST) serum tube


Specimen Volume: 9 uL plus a dead space of plasma or serum

Stability :Centrifuge and separate the plasma or serum from the cells immediately or within 2 hours of collection for transport.  Store separated samples at 6 days at 2-8ºC, and test within 3 days of collection. Sample is stable for 3 days at 20-25ºC and 24 months at -20ºC.  Freeze only once.

Reference Values

<300 pg/mL

Under 50 years of age:

NT-proBNP values below 300 pg/mL have a 98% negative predictive value for excluding acute congestive heart failure (CHF). For adults under 50 years of age with intact renal function, NT-proBNP values greater than 450 pg/mL have a positive predictive value of 76% for the diagnosis of CHF. For patients with an eGFR below 60, a cutoff of 1,200 pg/mL yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF.

 

50 to 75 years of age:

NT-proBNP values below 300 pg/mL have a 98% negative predictive value for excluding acute CHF. For adults 50 to 75 years of age with intact renal function, NT-proBNP values greater than 900 pg/mL have a positive predictive value of 83% for the diagnosis of CHF. For patients with an eGFR below 60, a cutoff of 1,200 pg/mL yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF.

 

Over 75 years of age:

NT-proBNP values below 300 pg/mL have a 98% negative predictive value for excluding acute CHF. For adults over 75 years of age with intact renal function, NT-proBNP values greater than 1800 pg/mL have a positive predictive value of 92% for the diagnosis of CHF. For patients with an eGFR below 60, a cutoff of 1,200 pg/mL yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF.

Day(s) Test Set Up

Monday through Sunday

Useful For

The N-terminal Pro-Brain Natriuretic Peptide test is used as an aid in the diagnosis and assessment of severity of heart failure

Methodology

Chemiluminescence

Test Classification and CPT Coding

83880

Report Available

Stat: 1 hr from receipt

Routine: 2 hrs from receipt